What is the mechanism of action for Griseofulvin?

• A. Binds to phospholipids in fungal membranes
• B. Inhibits fungal DNA synthesis
• C. Disrupts mitosis by interfering with microtubule function
• D. Inhibits squalene epoxidase

Answer: (C)

Griseofulvin acts by disrupting mitosis in fungal cells, specifically by interfering with microtubule function. This action is crucial because microtubules play a vital role in the formation of the mitotic spindle, which is necessary for the proper segregation of chromosomes during cell division. By disrupting this process, Griseofulvin effectively inhibits the growth and reproduction of fungi, making it an effective antifungal agent for treating dermatophyte infections.

The mechanism of action is thus distinct from simply targeting membranes, DNA synthesis, or lipid synthesis pathways, as seen in other antifungal agents. While other antifungal medications may focus on different cellular components or functions, Griseofulvin's unique targeting of the mitotic spindle highlights its specific role in halting fungal proliferation.